![AKLIEF® (trifarotene) Cream, 0.005% product packaging. AKLIEF® Cream box next to its bottle against a purple background](/content/images/product-packaging-purple-background.jpg)
AKLIEF Cream: AN INNOVATIVE APPROACH TO ACNE CARE.
AKLIEF Cream is the first retinoid cream with
proven results in treating facial and truncal
acne vulgaris.1
THE IMPORTANCE OF RAR-γ IN THE TREATMENT OF ACNE VULGARIS.
In a study of human skin biopsies, the percentage of RAR found in the skin was2:
![Magnified retinoic acid receptor-γ molecule represents AKLIEF® (trifarotene) Cream contains retinoids for acne treatment](/content/images/rar-y-molecule-magnified.png)
RAR-α (12-14%) and RAR-β (not detected) were significantly less prevalent.2
Targeting RAR-γ with retinoids for acne has several important functions in acne via gene modification2
- Inflammation modulated via AP-12
- Epidermal turnover and normalizing cell growth2
- Keratinization
- Desquamation
A UNIQUE ACNE TREATMENT DELIVERY SYSTEM.
![Molecule icon represents AKLIEF® (trifarotene) Cream Vehicle ingredient Simulgel® 600 PHA](/content/images/simulgel-600-pha-ingredient.png)
Simulgel® 600 PHA6
- Non-greasy
- Allows for homogenous dispersion of active ingredients
- Not sensitive to pH changes
![Droplets icon reflects AKLIEF® (trifarotene) Cream Vehicle emollient ingredients Cyclomethicone & medium-chain triglycerides](/content/images/emollients-ingredient.png)
2 emollients6-8
Cyclomethicone and medium-chain triglycerides allow for greater spreadability
![Droplet entering skin icon represents AKLIEF® (trifarotene) Cream Vehicle ingredient Allantoin](/content/images/allantoin-ingredient.png)
Allantoin6,8
A known skin-conditioning agent and protectant
![Leaf icon represents AKLIEF® (trifarotene) Cream Vehicle ingredient of being Paraben-free](/content/images/paraben-free-ingredient.png)
Paraben-free6
Emollients are mostly lipids and oils which hydrate and improve skin softness, flexibility, and smoothness.11
PHA=(P)olysorbate 80, Iso(H)exadecane, and copolymer of (A)crylamide.
AKLIEF Cream in action THE POWER OF PRECISION.
The first topical retinoid to specifically target RAR-γ, the most prevalent RAR in the skin.2,11
WATCH NOWPROVEN EFFICACY IN TREATING
ACNE VULGARIS IN
2,000+
PATIENTS ENROLLED IN
2 CLINICAL TRIALS11
RAPID RESULTS.* POWERFUL
EFFICACY. EXCELLENT TOLERABILITY.11
View Clinical Data
*Indicates a 2-week time frame on both the face and the trunk.11
![Teen female ready to return serve portrays confident patient using AKLIEF® (trifarotene) Cream prescription retinoid for acne](/content/images/teenage-female-tennis-player-return-serve.jpg)
ACNE THAT'S BEYOND WHAT'S IN PLAIN SIGHT.
Patients with truncal acne may not freely talk about it with their doctors for various reasons. However, if left untreated, it can have a negative impact on their daily lives.6,10