Me Being Me, brought to you by AKLIEF® (trifarotene) Cream, 0.005%: Don’t let acne breakouts affect the vibe you project, whether you’re video chatting for work or play.

Me Being Me logo by AKLIEF® (trifarotene) Cream, 0.005%, represents treating acne so the focus stays on you, not your acne!


Discover why AKLIEF® (trifarotene) Cream, 0.005% acne treatment may be right for you.

Not an actual patient.

With AKLIEF Cream


AKLIEF Cream is an innovative topical single agent retinoid cream proven safe and effective for acne on your face, shoulders, chest, and back.1-3 AKLIEF Cream contains the retinoid molecule trifarotene, which helps the skin replace its old skin cells at a faster speed, exfoliating away the old cells in the process and helps prevent new acne from forming.1 It may also reduce inflammatory acne often experienced with pimples.

AKLIEF® (trifarotene) Cream, 0.005% product packaging - AKLIEF® Cream bottle next to its box against a white background
Real patient testimonial video thumbnail of Natalie who speaks of successfully using AKLIEF® Cream prescription acne treatment


Teenage girl determined to return tennis serve represents confidence having clearer skin using AKLIEF® Cream acne medication

Target acne vulgaris with a secret weapon: TRIFAROTENE.

Precise & Selective
The active ingredient in AKLIEF Cream is trifarotene, an innovative retinoid molecule that targets important factors that cause acne.1

Treating From All Angles
AKLIEF Cream starts to work quickly and is proven to be effective in treating acne on the face as well as the chest, shoulders, and back.1,3

The exact process by which trifarotene ameliorates acne is unknown.

Frequently asked questions:


What is AKLIEF Cream?

AKLIEF Cream is an innovative prescription acne treatment proven effective for the face, shoulders, chest, and back.1
The active ingredient in AKLIEF Cream, trifarotene, works by specifically targeting the retinoic acid receptor gamma (RAR-γ), the most prevalent receptor in the skin, to reduce inflammation and target other important factors that cause acne.1

The exact process by which trifarotene ameliorates acne is unknown.
AKLIEF Cream is a prescription retinoid indicated for the topical treatment of acne vulgaris in patients 9 years of age and older.3
AKLIEF Cream may help reduce inflammatory acne and comedonal acne (more commonly known as blackheads and whiteheads).1
Yes, the FDA has approved AKLIEF Cream as a prescription acne medication in 2019. Trifarotene, the active ingredient in AKLIEF Cream, is the first new retinoid molecule to receive FDA approval for the treatment of acne in more than 20 years.2
Retinol is a form of vitamin A that is commonly used in over-the-counter creams to treat skin conditions like acne.4 AKLIEF Cream contains the first topical retinoid molecule approved to treat acne in 20 years.2
Treating acne doesn’t have to break the bank. The Galderma® CAREConnect Patient Savings Card works like an AKLIEF Cream coupon, offering instant savings on your prescriptions and refills. To start saving, click here.* You will be redirected to download your patient savings card.
Most insurance plans cover AKLIEF Cream. Check with your insurance provider to learn more. You can also download the Galderma CAREConnect Card that may give you instant savings on your prescriptions and refills.*
The active ingredient in AKLIEF Cream is trifarotene, an innovative retinoid molecule that targets important factors that cause acne.1
In clinical trials, people using AKLIEF Cream showed a significant reduction in facial acne lesions as early as 2 weeks. However, individual results may vary.1
You should apply AKLIEF Cream to the affected area once a day in the evening. If you have to be in sunlight or are sensitive to sunlight, use sunscreen with a sun protection factor (SPF) of 15 or more, and wear protective clothing and a wide-brimmed hat to cover the treated areas.3
For your face, use 1 pump. For your upper back, shoulders, and chest, use 2 pumps. If needed, you may use an additional pump for your middle to lower back.3 To learn more about how to apply AKLIEF Cream, go here.
If you can’t reach or don’t have anyone to help, applicators can be used to help you apply the cream where it’s needed.3
Don’t double the dose to make up for the forgotten one. Just continue the next day with the same amount of product. Try and keep using it as your dermatology provider instructed to get the most out of your treatment.3
Avoid contact with your eyes, lips, mouth, the corners of your nose, and vagina.3
Minimize exposure to sunlight. You should avoid using sunlamps, tanning beds, and ultraviolet light during treatment with AKLIEF Cream. If you have to be in sunlight or are sensitive to sunlight, use a sunscreen with an SPF (sun protection factor) of 15 or more, and wear protective clothing and a wide-brimmed hat to cover the treated areas. Avoid using skin products that may dry or irritate your skin, such as:
  • medicated or abrasive soaps and cleansers
  • soaps, cleansers, and cosmetics that have strong skin-drying effects
  • products that contain high amounts of alcohol
Avoid the use of “waxing” as a hair removal method on skin treated with AKLIEF Cream.3
You may notice your facial acne improving as early as 2 weeks. In clinical trials, patients were asked to use AKLIEF Cream for 12 weeks.1 You should continue with your treatment as your dermatology provider directed.
There’s a chance your acne could come back when you stop AKLIEF Cream. That doesn’t mean the treatment didn’t work properly, but pores can become clogged again, causing acne to reappear. Follow your dermatology provider’s instructions on your treatment using AKLIEF Cream.3
Applying the recommended amount, following your dermatology provider’s instructions, and using AKLIEF Cream consistently on your face, chest, shoulders, or back can help keep acne from getting in your way.3 Find out how easy it is to follow a daily acne treatment routine.
  • Clean your skin gently, with a mild, non-abrasive soap, at least once a day3,5
  • Use skincare products that won’t clog your pores. Look for “non-comedogenic” or “oil-free” labels on the packaging5
  • Wash your skin after exercise5
  • Wear loose-fitting clothing5
  • Discover more skincare tips
Store AKLIEF Cream at room temperature, 68° to 77° F (20° to 25° C).3
  • Keep AKLIEF Cream away from light and heat
  • If you receive a sample tube of AKLIEF Cream from your dermatology provider, keep the tube tightly closed
Keep AKLIEF Cream and all medicines out of the reach of children.3
The most common side effects of AKLIEF Cream include: application site irritation, itching, and sunburn.3

AKLIEF Cream may cause serious side effects, including: Local skin irritation. Local skin reactions are common with AKLIEF Cream and are most likely to happen during the first 4 weeks of treatment and may decrease with continued use of AKLIEF Cream. Signs and symptoms of local skin reactions include3:
  • redness
  • scaling
  • dryness
  • stinging or burning
To help reduce your risk of developing these local skin reactions, when you begin treatment with AKLIEF Cream, you should begin applying a moisturizer on your skin as often as needed.3

Tell your doctor if you develop symptoms of a local skin reaction. Your dermatology provider may tell you to use AKLIEF Cream less often, or to temporarily or permanently stop your treatment with AKLIEF Cream.3

These are not all the possible side effects of AKLIEF Cream.3 For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA 1088.

You may also report side effects to GALDERMA LABORATORIES, L.P. at 1-866-735-4127.3
With a prescription from your dermatology provider, AKLIEF Cream can be purchased at most pharmacies including CVS and Walgreens.

*Certain limitations may apply. Click here for program details.

The Galderma® CAREConnect™ Program (“Program”) is brought to you by Galderma Laboratories, L.P. (“Galderma”). The Program is only available for commercially unrestricted or commercially restricted/cash paying patients. Patients who are enrolled in state or federally government-run or government-sponsored healthcare plan with a pharmacy benefit are not eligible to use the Galderma CAREConnect Patient Savings Card (“Card”). Any claim under the Program must be submitted by participating pharmacies to one of the Administrators of the Program.

References: 1. AKLIEF Press Release. Federal Drug Administration approval, 2019. 2. AKLIEF® (trifarotene) Cream 0.005% [Prescribing Information]. Ft Worth, TX: Galderma Laboratories, L.P.; October 2019. 3. Tan J, Thiboutot D, Popp G, et al. Randomized phase 3 evaluation of trifarotene 50 µg/g cream treatment of moderate facial and truncal acne. J Am Acad Dermatol. 2019;80(6):1691-1699. 4. Aubert J, Piwnica D, Bertino B, et al. Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor-γ agonist trifarotene. Br J Dermatol. 2018;179(2):442-456. 5. Back acne: how to see clearer skin. American Academy of Dermatology Association. Accessed July 27, 2021.


Indication: AKLIEF® (trifarotene) Cream, 0.005% is a retinoid indicated for the topical treatment of acne vulgaris in patients 9 years of age and older. Adverse Events: The most common adverse reactions (incidence ≥ 1%) in patients treated with AKLIEF Cream were application site irritation, application site pruritus (itching), and sunburn. Warnings/Precautions: Patients using AKLIEF Cream may experience erythema, scaling, dryness, and stinging/burning. Use a moisturizer from the initiation of treatment, and, if appropriate, depending upon the severity of these adverse reactions, reduce the frequency of application of AKLIEF Cream, suspend or discontinue use. Avoid application of AKLIEF Cream to cuts, abrasions or eczematous or sunburned skin. Use of “waxing” as a depilatory method should be avoided on skin treated with AKLIEF Cream. Minimize exposure to sunlight and sunlamps. Use sunscreen and protective clothing over treated areas when exposure cannot be avoided.


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

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